The Twilight vampire romance series took home four People’s Choice trophies, including favourite movie, favourite franchise and top on-screen team for its actors.
One of its stars, Taylor Lautner, landed the award for breakthrough movie actor.
Other key movie winners were Johnny Depp, who was named favourite movie actor, and Hugh Jackman, who claimed the trophy for top action hero for his role in the comic book movie X-Men Origins: Wolverine.
Television honours went to House for best drama and The Big Bang Theory for top comedy.
Music trophies were claimed by Carrie Underwood for favourite country singer and Taylor Swift for top female artist, while Keith Urban was named top male singer and Mariah Carey named favourite R&B artist.
But it was Bullock who had a big night with a People’s Choice honour in each hand following two major hits in 2009, The Proposal and The Blind Side, in which she plays a woman who helps transform a homeless youngster into an American football star.
Her work already has earned the actress Golden Globe and Screen Actors Guild award nominations, and she is among the favourites for an Oscar nod for her work in The Blind Side.
On stage, she teared up when accepting her second People’s Choice award, which is voted upon by fans in an online poll, and thanked her family, father, husband and fans.
She told reporters her recent success with critics, awards and at box offices was “unplanned, unexpected and unreal.”
“I’ve had two wonderful experiences this year, and I think most actresses will tell you if you had one in five years you’d be lucky,” she said.
The People’s Choice awards are considered less serious by Hollywood watchers than the Oscars or Screen Actors Guild honours, which are voted upon by industry groups, but they are widely watched because they kick off about two months of awards in film, television and music that will be given out.
Moreover, actors, musicians and other artists consider them an honour because fans do the voting.
Some 35 awards were given out in all and among other top honours, animated Disney film Up was favourite family movie.
In TV, top-rated American Idol won best competition program, while House star Hugh Laurie was best drama actor and Katherine Heigl favourite drama actress.
Alyson Hannigan won best comedy actress for her work in How I Met Your Mother and Steve Carell top comedy actor in The Office.
Other music winners included Lady Gaga as favourite pop artist and breakout music artist. Paramore was favourite rock band and Eminem best hip-hop artist.