The 30-year-old wore a black A-line Carrie Hammer dress for her groundbreaking appearance.
The outfit was a nod to her role on the dark Tv series American Horror Story.
Carrie Hammer chose the actress to appear in her show as part of her “Role Models not Runway Models” campaign.
The designer started the initiative in 2014 after being left disgruntled with having to use young models with body types that didn’t reflect those who would be wearing her designs.
Instead, Hammer invited friends and customers to wear her clothes on the catwalk.
Fans were treated to pre-show excitement with a tweet from the make-up artist’s chair and a glimpse of the catwalk rehearsal on instagram.
“It’s amazing, it’s really neat. Many women have many sides to their personality, this dress fits…mine,” she says. “I am honoured to be in it,” Brewer said ahead of her history-making runway walk.
It’s not the first time the designer has helped make history in the fashion world.
Last year’s NYFW show, saw doctor and sex therapist Danielle Sheypuk take to the runway in her wheelchair.
Hammer has also invited a transgender woman, racing car driver, a veteran and government workers to model her clothing.