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Breast cancer study raises questions over value of mammograms

One in three women with breast cancer detected by a mammogram is treated unnecessarily, according to a Danish study.

Breast cancer study raises questions over value of mammograms

A new breast cancer study raises questions over mammograms, saying one in three women is treated unnecessarily

Breast cancer study raises questions over value of mammograms

One in three women with breast cancer detected by a mammogram is treated unnecessarily, according to a Danish study published today in Annals of Internal Medicine, which has renewed debate over the value of early detection.

The women didn’t need treatment, researchers write, because they had tumours so slow-growing that they were essentially harmless.

The study raises the uncomfortable possibility that some women who believe their lives were saved by mammograms were actually harmed by cancer screenings that led to surgery, radiation and even chemotherapy that they didn’t need, said Dr Otis Brawley. He is chief medical officer of the American Cancer Society and wrote an accompanying editorial but was not involved in the study.

Researchers increasingly recognise not all breast cancers pose the same risk, even if they look the same under a microscope, Brawley said.

While some early tumours turn into deadly monsters, others stop growing or even shrink. But assuming that all small breast lesions have the potential to turn deadly is akin to “racial profiling,” Brawley wrote in his editorial.

“By treating all the cancers that we see, we are clearly saving some lives,” Brawley said in an interview. “But we’re also ‘curing’ some women who don’t need to be cured.”

Although experts such as Brawley have long discussed the risks posed by “over-diagnosis, relatively few women who undergo cancer screenings are even aware of the debate.

The American College of Radiology, which strongly supports breast cancer screenings, acknowledges that mammograms lead some women to be treated unnecessarily but said the problem is much less common than the new study suggests.

Another study from Denmark – where the national health programme keeps detailed records – estimated the over-diagnosis rates at only 2.3%.

“The amount of over-diagnosis really is small,” said Dr Debra Monticciolo, chair of the American College of Radiology’s commission on breast imaging.

Yet treating women for cancer unnecessarily can endanger their health, said Fran Visco, president of the US National Breast Cancer Coalition, an advocacy group. Radiation can damage the heart or even cause new cancers.

Visco notes that breast cancer activist Carolina Hinestrosa, a vice-president at the coalition, died at age 50 from soft-tissue sarcoma, a tumour caused by radiation used to treat an early breast cancer.

Women should understand these risks, Visco said. Instead, women often hear only about mammograms’ benefits.

“Women have been inundated with the early detection message for decades,” Visco said.

The risks of over-diagnosis and false positives, which can lead women with benign growths to undergo biopsies and other follow-up tests, have caused some experts to re-evaluate breast cancer screenings.

Although mammograms don’t find all tumours, they reduce the risk of dying from breast cancer by 25% to 31% for women ages 40 to 69, according to the Agency for Healthcare Research and Quality, part of the US Department of Health and Human Services.

Medical groups now offer differing advice on mammograms.

The American College of Radiology takes the most aggressive stance, recommending annual mammograms beginning at age 40. Tumours should be found when they’re “smaller and easier to treat,” Monticciolo said.

The US Preventive Services Task Force, an independent expert panel that advises the federal government on health, provoked a firestorm of criticism in 2009 when it recommended mammograms every other year beginning at age 50. The group noted that breast cancer risk rises with age, so mammograms are more likely to discover cancer – as opposed to benign growths – after age 50.

The American Cancer Society also scaled back its screening advice in 2015, recommending annual mammograms from 45-54, followed by screenings every other year after that.

In the new study, Danish researchers estimated the rate of over-diagnosis by comparing the number of early-stage and advanced breast tumours before and after the country started offering mammograms.

If screenings work as intended, the number of small, curable breast tumours should increase, while reducing the number of large cancers by about the same amount.

Although mammograms in Denmark detected a lot more breast cancers, these were mostly small, early-stage tumours, said Dr Karsten Jorgensen, a researcher at the Nordic Cochrane Centre in Copenhagen. The number of advanced cancers did not fall.

The debate illustrates the limits of medical technology, Brawley said. Although researchers can estimate the statistical rate of over-diagnosis, doctors treating actual patients can’t definitively tell which breast tumours need treatment and which might be safely ignored. So doctors tend to err on the side of caution and treat all breast cancers with surgery and, in many cases, radiation and chemotherapy.

Breast cancer is the most common cancer in New Zealand and Australian women.

New Zealand‘s publicly funded BreastScreen Aotearoa programme was launched in December 1998 and offers free mammograms to eligible women aged 45-69. Over 600 women die from breast cancer each year.

BreastScreen Australia invites women aged 50-74 for a free mammogram every two years. It is estimated 3073 people (27 men and 3046 women) died from breast cancer in 2016.

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