Laser offers solution for sun-damaged skin

A procedure using a topical solution and laser treatment stimulates collagen production and helps rejuvenate sun-damaged skin, US researchers say.

Their study confirmed the value of a procedure already being performed by some doctors to improve the appearance of skin with wrinkles, fine lines and “sun spots”, and helps explain how it works.

University of Michigan researchers tested photodynamic therapy that combines a clear solution, made by DUSA Pharmaceuticals and called Levulan, which is dabbed onto the skin to increase its sensitivity to light, and so-called pulsed dye laser treatment using brief flashes of a single wavelength of light.

In a group of 15 women and 10 men aged 54 to 83 with sun-damaged skin, the researchers found that the therapy increased production of collagen – a protein that helps provide skin its texture and elasticity – and promoted the thickening of the top layer of the skin.

“We do believe that the treatment would, in fact, improve the appearance of patients’ skin,” Dr Jeffrey Orringer, director of the University of Michigan’s Cosmetic Dermatology and Laser Center, said.

“It lends molecular or scientific credibility to a procedure that’s being done out there, and it’s also the first step in understanding how to make this treatment more effective,” Orringer said.

No industry money was used to fund the study published in the journal Archives of Dermatology, Orringer said.

The researchers performed the procedure on sun-damaged forearm skin of the 25 volunteers and took tissue samples to examine the changes in the skin.

Many people are eager to improve the appearance of skin damaged by years of sunbathing or other exposure to the sun.

Photodynamic therapy currently being performed, often on the face, can cost hundreds of dollars, Orringer said.

The US Food and Drug Administration approved Levulan in 1999 to treat precancerous skin lesions of the face or scalp called actinic keratoses. It is also used “off-label” in photodynamic therapy to make sun-damaged skin look better.

Collagen production was twice as great with Levulan plus laser treatment compared to laser treatment alone, he said.

The laser treatment feels like a rubber band snapping on the skin, but is less painful than laser tattoo removal, Orringer said.


Share on Facebook Pin on Pinterest Share by Email
Share To

More than skin deep

Acne is the medical term for a common skin disease that includes a range of symptoms, from the occasional spot or pimple to blackheads, whiteheads and more severe large cysts and swellings.

It affects 85 per cent of Australians and New Zealanders aged 15 to 24 and, increasingly, women 
in their 20s, 30s and 40s.

While it’s not understood why some people suffer from more severe acne than others, the cause is known to be a blockage of the opening of the oil glands in the skin. When these sebaceous glands are functioning normally, they produce sebum to keep the skin supple and healthy.

However, overproduction of sebum leads to excess oil, which, along with a buildup of dead skin cells, clogs the pores and causes blemishes.

Acne is often deemed a teenage condition, because of its tendency to begin at puberty when increased hormone levels send oil production into overdrive, but it can occur at any age. Adolescent boys and young men are more likely to have severe acne, while females are more prone to suffering ongoing acne or developing acne after puberty.


Acne can be classified as either mild, 
moderate or severe. Mild acne is 
limited to clusters of whiteheads and blackheads that tend not to cover large areas of the face or body.

Moderate acne is characterised by papules (raised, reddish bumps) or pustules (pimples containing pus) that are widespread on the face or body and are more difficult to eradicate than the average pimple.

Severe, or cystic, acne is beyond the realm of the occasional breakout, and causes deep, solid, painful lumps or cysts under the skin that cover large areas of the face and body.

About 5 per cent of Australians and New Zealanders develop cystic acne. The concerns are more than skin deep, as cystic acne can have a devastating psychological impact on sufferers.

Studies have linked the condition with social isolation, self-consciousness, low self-esteem, reduced employment prospects, depression and anxiety.

Other forms of acne include adult, or hormonal, acne, which affects 20–30 per cent of women aged between 20 and 40, and acne resulting as a symptom of polycystic ovarian syndrome (PCOS), a disorder that affects 10 per cent of women.


The specific causes of acne will vary according to the individual, says 
Dr JoAnn See, a Sydney dermatologist 
and co-chair of All About Acne.

In women, PCOS (a hormonal imbalance where the body produces excess androgens that stimulate the production of sebum) should be ruled out as the cause of their acne before considering other possible causes.

In adolescents, acne can generally be attributed to fluctuating hormones brought on by puberty, particularly in young males, as they have higher levels 
of androgens.

It’s also believed that the tendency for the sebaceous glands to become blocked may be genetic, so a family history may increase the chances of developing acne.

Other possible causes of acne in both teenagers and adults include:

> poor skincare

> using pore-clogging skincare products, or facial sunscreens with a high SPF

> dietary factors, particularly a high intake of dairy and high-GI foods

> excess body weight in women, 
where surplus fat converts the female hormone oestrogen into hormones that behave like androgens, thus causing overproduction of sebum

> high-dose progesterone contraceptive pills, the minipill and contraceptive implants, which boost sebum production

> stress, which may encourage overproduction of male hormones

> metabolic abnormalities, such as high insulin levels

> pregnancy, which may cause hormonal acne to flare in the first trimester.


Dr See says self-diagnosis can be risky, especially as sufferers often aren’t sure 
if their acne is mild, moderate or severe. 
“A doctor or dermatologist can usually tell you what type of acne you have simply by observing the number, type and depth of the acne spots,” she says.

While the odd monthly blemish doesn’t warrant medical attention, 
Dr See says pimples, lesions or painful cysts that are widespread, recurring or won’t clear – and are causing distress, social withdrawal, embarrassment or depression – should be addressed with the help of a medical professional.


Unfortunately, there is no magic cure or quick fix for acne, and Dr See stresses that treatment is largely individual; what works in one case might not produce the same results in another. Also, treatments for mild acne differ greatly to strategies for severe cystic acne, making it important to discuss the best options for your condition with your GP or dermatologist.


The number-one rule for treating acne is to consult a healthcare practitioner, such as a dermatologist, about appropriate skincare. In addition, Dr See says that following a simple “cleanse, treat, protect” regimen is important for everyone with acne. Look for a mild liquid face cleanser that is acid and/or pH balanced and free from soap, abrasives and alcohol.

Cleansing should be followed by the application of a specialised acne treatment product. Only make-up, moisturisers and sunscreens that are non-comedogenic (won’t block the pores) should be used.


Antibiotic creams, gels or capsules may be prescribed to control the bacterial infection that contributes to acne, and to reduce redness, swelling and pain.

Your doctor may prescribe an acne medication that is a vitamin A derivative; however, be aware that some of these have been linked with clinical depression.

Hormonal acne treatment in the form of the oral contraceptive pill is sometimes recommended for women over 25 years 
of age, or those experiencing premenstrual acne flare-ups, as the pill can block the stimulatory effect of androgens on the sebaceous glands. However, remember the pill has been linked with various disorders, ranging from heart disease to depression.


Taking zinc and vitamin A supplements and using tea-tree oil as a topical lotion have proven beneficial in treating mild to moderate acne. Products containing colloidal oatmeal (oats ground into 
fine powder) can have a soothing effect 
on dry, irritated skin and sores.


The role of diet in treating acne is controversial, says Dr See. However, an RMIT University study published in 2007 found a link between a low-GI diet and reduced acne in males aged 15 to 25. Some sufferers report dairy products as an acne trigger, but Dr See says reactions to certain foods differ between individuals, and the myth that diet alone causes acne is false.


Laser and other light therapies, which can reduce the incidence of Propionibacterium acnes – the bacterium that causes the inflammation in acne – may be useful 
in treating active acne and acne scars.

A small UK study published in 2003 found that a single pulsed dye laser (PDL) treatment reduced lesions on the face by half in cases of mild to moderate acne. The improvement was evident for two weeks to three months after treatment.

Dr Glen Calderhead, a researcher of light therapy and a proponent of the Omnilux system, says: “Two independent trials have found success rates of 79–90 per cent for improving inflammatory acne using a combination of blue and red light therapy twice a week for four weeks. The blue light kills the bacteria, then the red light stimulates blood flow and improves oxygenation, helping to clear the skin.”

A dermatologist can help you find the best treatment to minimise acne scarring and achieve visible improvement.


“There appears to be a growing trend for teenagers 
to self-treat their acne with celebrity-endorsed products,” says dermatologist Dr JoAnn See.

While some of these products can help to reduce acne, they don’t work for everyone. “Paying a lot of money for products to help with acne does not mean they’re the right products,” 
Dr See says.

“Decisions [about treatment options] need to be tailored to the individual’s needs, and that’s something that requires the advice of 
a healthcare professional.”


Some natural therapists believe that breakouts on certain areas of the face correspond to weakness or toxicity of a particular organ. They will therefore focus directly on treating the organ rather than the skin.

Breakouts on the forehead are linked to the intestines; the chin area is linked to the reproductive organs; the area between the nose and upper lip is linked to the stomach; and the bridge of the nose is linked to the spleen.


All About Acne,

Australasian College of 

DermNet NZ,

Share on Facebook Pin on Pinterest Share by Email
Share To